NDR1 / STK38 Antibody (C-Term, near)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q15208 |
Other Accession | NP_009202.1, 11329, 361813 (rat) |
Reactivity | Human, Rat |
Predicted | Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 54190 Da |
Gene ID | 11329 |
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Other Names | Serine/threonine-protein kinase 38, 2.7.11.1, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH12085.1} |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NDR1 / STK38 Antibody (C-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STK38 {ECO:0000303|PubMed:17906693, ECO:0000312|HGNC:HGNC:17847} |
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Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono- ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). |
Cellular Location | Nucleus. Cytoplasm. Chromosome Note=Localizes to DNA double-strand breaks in response to DNA damage |
Tissue Location | Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is NOT expected to cross-react with STK38L (GeneID 23012).
References
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Kohler RS, Schmitz D, Cornils H, Hemmings BA, Hergovich A, Molecular and cellular biology 2010 Sep 30 (18): 4507-20. PMID: 20624913
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