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KCTD11 Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - KCTD11 Antibody (internal region) AF3376a
    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCTD11 with DYKDDDDK tag probed with AF3376a (1.0ug/ml) in Lane A and probed with anti-DYKDDDDK Tag (1/5000) in lane C. Mock-transfected HEK293 probed with AF3376a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q693B1
Other Accession NP_001002914.1, 147040, 216858 (mouse), 363634 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 25887 Da
Additional Information
Gene ID 147040
Other Names BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCTD11 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCTD11
Synonyms C17orf36, REN
Function Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down- regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Tissue Location Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma.
Research Areas
Citations (0)
citation

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References

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Di Marcotullio L, Ferretti E, De Smaele E, Argenti B, Mincione C, Zazzeroni F, Gallo R, Masuelli L, Napolitano M, Maroder M, Modesti A, Giangaspero F, Screpanti I, Alesse E, Gulino A, Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 101 (29): 10833-8. PMID: 15249678

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$ 341.00
Cat# AF3376a
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