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TRIM29 / ATDC Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - TRIM29 / ATDC Antibody (internal region) AF3094a
    AF3094a (1 µg/ml) staining of Peripheral Blood Lymphocytes lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
    detail
  • IHC - TRIM29 / ATDC Antibody (internal region) AF3094a
    AF3094a (3.8 µg/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q14134
Other Accession NP_036233.2, 23650, 72169 (mouse), 300656 (rat)
Reactivity Human
Predicted Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 65835 Da
Additional Information
Gene ID 23650
Other Names Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM29 / ATDC Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM29
Synonyms ATDC
Function Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Cellular Location Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments
Tissue Location Expressed in placenta, prostate and thymus.
Research Areas
Citations (0)
citation

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References

Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Wang L, Heidt DG, Lee CJ, Yang H, Logsdon CD, Zhang L, Fearon ER, Ljungman M, Simeone DM, Cancer cell 2009 Mar 15 (3): 207-19. PMID: 19249679

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$ 341.00
Cat# AF3094a
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Availability: 7-10 days
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