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DEFA1/3 precursor Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P59666 |
| Other Accession | NP_004075.1, NP_005208.1, 1667, 1668 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 10245 Da |
| Gene ID | 1668 |
|---|---|
| Other Names | Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DEFA1/3 precursor Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DEFA3 |
|---|---|
| Synonyms | DEF3 |
| Function | Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766). |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to equally recognize DEFA1 precursor and DEFA3 precursor.
References
Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. Chang TL, Vargas J Jr, DelPortillo A, Klotman ME. J Clin Invest. 2005 Mar;115(3):765-73. PMID: 15719067
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