STK36 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q9NRP7 |
Other Accession | NP_056505.1, 27148 |
Predicted | Human, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 143995 Da |
Gene ID | 27148 |
---|---|
Other Names | Serine/threonine-protein kinase 36, 2.7.11.1, Fused homolog, STK36 {ECO:0000312|EMBL:AAH26158.1} |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | STK36 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STK36 {ECO:0000312|EMBL:AAH26158.1} |
---|---|
Function | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. |
Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Note=Low levels also present in the nucleus. |
Tissue Location | Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells (PubMed:10806483). Expressed in respiratory epithelial cells of the lung (PubMed:28543983). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, Finta C, Osterlund T, Kogerman P. Journal of Cell Communication and Signaling 2007 Dec 1 (3-4): 165-73. PMID: 18600476
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.