HRASLS2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, E |
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Primary Accession | Q9NWW9 |
Other Accession | NP_060348.1, 54979 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 17394 Da |
Gene ID | 54979 |
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Other Names | HRAS-like suppressor 2, 2.3.1.-, 3.1.1.-, HRASLS2 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HRASLS2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLAAT2 (HGNC:17824) |
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Synonyms | HRASLS2 |
Function | Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852). |
Cellular Location | Cytoplasm. Membrane; Single-pass membrane protein Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. |
Tissue Location | Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This design was based on provisional sequence data.
References
Cloning and functional characterization of the HRASLS2 gene. Shyu RY, Hsieh YC, Tsai FM, Wu CC, Jiang SY. Amino Acids. 2008 Jun;35(1):129-37. PMID: 18163183
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