GDF2/BMP9 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q9UK05 |
Other Accession | NP_057288.1, 2658 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 47320 Da |
Gene ID | 2658 |
---|---|
Other Names | Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9, GDF2, BMP9 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GDF2/BMP9 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GDF2 |
---|---|
Synonyms | BMP9 |
Function | Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. |
Cellular Location | Secreted |
Tissue Location | Detected in blood plasma (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
References
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW, ten Dijke P. J Cell Sci. 2007 Mar 15;120(Pt 6):964-72. Epub 2007 Feb 20. PMID: 17311849
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