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CHRFAM7A / CHRNA7-FAM7A Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P36544 |
| Other Accession | NP_647536.1, 89832 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 56449 Da |
| Gene ID | 1139;89832 |
|---|---|
| Other Names | Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CHRFAM7A / CHRNA7-FAM7A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHRNA7 |
|---|---|
| Synonyms | NACHRA7 |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity) {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:27789755} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoform NP_647536.1 only.
References
Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. Martin LF, Leonard S, Hall MH, Tregellas JR, Freedman R, Olincy A. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):611-4. PMID: 17192894
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