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SENP7 (internal region) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9BQF6 |
| Other Accession | NP_001070671.1, NP_065705.3, 57337, 66315 (mouse), 288167 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 119658 Da |
| Gene ID | 57337 |
|---|---|
| Other Names | Sentrin-specific protease 7, 3.4.22.68, SUMO-1-specific protease 2, Sentrin/SUMO-specific protease SENP7, SENP7, KIAA1707, SSP2, SUSP2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SENP7 (internal region) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SENP7 {ECO:0000303|Ref.2, ECO:0000312|HGNC:HGNC:30402} |
|---|---|
| Function | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_001070671.1; NP_065705.3)
References
Differential regulation of sentrinized proteins by a novel sentrin-specific protease. Gong,L., Millas,S., Maul,G.G. and Yeh,E.T J. Biol. Chem. 275 (5), 3355-3359 (2000) PMID: 10652325
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