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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > TRPM8 Antibody (internal region)
TRPM8 Antibody (internal region)
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q7Z2W7 |
| Other Accession | NP_076985.4, 79054, 171382 (mouse), 171384 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 127685 Da |
| Gene ID | 79054 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRPM8 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPM8 |
|---|---|
| Synonyms | LTRPC6, TRPP8 |
| Function | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft {ECO:0000250|UniProtKB:Q8R4D5}. Endoplasmic reticulum membrane. Note=Lipid raft association modulates TRPM8 channel activity (By similarity) Located in the endoplasmic reticulum in prostate cancer cells (PubMed:11325849, PubMed:16174775). {ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:16174775} |
| Tissue Location | Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
TRPM8 is required for cold sensation in mice. Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. Neuron. 2007 May 3;54(3):371-8. PMID: 17481391
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$ 216.00
Cat# AF2715a
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