RIG1 / RARRES3 (aa 124 to 136) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q9UL19 |
Other Accession | NP_004576.2, 5920 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 18179 Da |
Gene ID | 5920 |
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Other Names | Retinoic acid receptor responder protein 3, 3.1.1.-, HRAS-like suppressor 4, HRSL4, RAR-responsive protein TIG3, Retinoid-inducible gene 1 protein, Tazarotene-induced gene 3 protein, RARRES3, RIG1, TIG3 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RIG1 / RARRES3 (aa 124 to 136) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLAAT4 (HGNC:9869) |
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Synonyms | RARRES3, RIG1, TIG3 |
Function | Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858). |
Cellular Location | Membrane; Single- pass membrane protein |
Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
References
RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Tsai FM, Shyu RY, Jiang SY. Cell Signal. 2007 May;19(5):989-99. Epub 2006 Nov 23. PMID: 17196792
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