MSH5 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, E |
---|---|
Primary Accession | O43196 |
Other Accession | NP_079535.3, NP_751897.1, NP_002432.1, 4439, 17687 (mouse), 294252 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 92875 Da |
Gene ID | 4439 |
---|---|
Other Names | MutS protein homolog 5, hMSH5, MSH5 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MSH5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MSH5 |
---|---|
Function | Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). |
Tissue Location | Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:28175301, PubMed:9740671) Also expressed in fetal ovary and adrenal gland (PubMed:28175301) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise three reported isoforms ( NP_079535.3 ; NP_751897.1; NP_002432.1); Reported variants NP_751898.1 and NP_002432.1 represent identical protein.
References
CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization. Neyton S, Lespinasse F, Lahaye F, Staccini P, Paquis-Flucklinger V, Santucci-Darmanin S. Exp Cell Res. 2007 Oct 15;313(17):3680-93. Epub 2007 Aug 21. PMID: 17869244
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