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Phorbolin 1 / APOBEC3A Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • IHC - Phorbolin 1 / APOBEC3A Antibody (internal region) AF2685a
    AF2685a (3.8 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession P31941
Other Accession NP_663745.1, 200315
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 23012 Da
Additional Information
Gene ID 100913187;200315
Other Names DNA dC->dU-editing enzyme APOBEC-3A, A3A, 3.5.4.-, Phorbolin-1, APOBEC3A
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhorbolin 1 / APOBEC3A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOBEC3A
Function DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non- lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Research Areas
Citations (0)
citation

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References

Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity. Goila-Gaur R, Khan MA, Miyagi E, Kao S, Strebel K. Retrovirology. 2007 Aug 29;4:61. PMID: 17727729

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$ 341.00
Cat# AF2685a
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Availability: 7-10 days
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