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BAG5 (internal) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9UL15 |
| Other Accession | NP_001015048.1, NP_001015049.1, NP_004864.1, 9529, 70369 (mouse), 366734 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 51200 Da |
| Gene ID | 9529 |
|---|---|
| Other Names | BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5, BAG5, KIAA0873 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BAG5 (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BAG5 |
|---|---|
| Synonyms | KIAA0873 |
| Function | Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). |
| Cellular Location | Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes {ECO:0000250|UniProtKB:Q8CI32} |
| Tissue Location | Expressed in the heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise reported isoforms a (NP_001015049.1) and b (NP_001015048.1, NP_004864.1).
References
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM. Neuron. 2004 Dec 16;44(6):931-45. PMID: 15603737
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