NGFRAP1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q00994 |
Other Accession | NP_996800.1, NP_996798.1, NP_055195.1, 27018 |
Predicted | Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 12959 Da |
Gene ID | 27018 |
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Other Names | Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NGFRAP1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BEX3 (HGNC:13388) |
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Synonyms | DXS6984E, NADE, NGFRAP1 |
Function | May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9} |
Tissue Location | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise isoform a (NP_996800.1) and isoform b (NP_996798.1 and NP_055195.1).
References
Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Passino MA, Adams RA, Sikorski SL, Akassoglou K. Science. 2007 Mar 30;315(5820):1853-6. PMID: 17395831
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