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CTDSP1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9GZU7 |
| Other Accession | NP_067021.1, NP_872580.1, 58190, 227292 (mouse), 363249 (rat) |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 29203 Da |
| Gene ID | 58190 |
|---|---|
| Other Names | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, 3.1.3.16, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTDSP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTDSP1 |
|---|---|
| Synonyms | NIF3, NLIIF, SCP1 |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| Cellular Location | Nucleus. Note=Colocalizes with RNA polymerase II |
| Tissue Location | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms (NP_067021.1and NP_872580.1).
References
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Mol Cell. 2006 Dec 8;24(5):759-70. PMID: 17157258 [PubMed - indexed for MEDLINE
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