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ITPR3 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q14573 |
| Other Accession | NP_002215.2, 3710 |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 304106 Da |
| Gene ID | 3710 |
|---|---|
| Other Names | Inositol 1, 4, 5-trisphosphate receptor type 3, IP3 receptor isoform 3, IP3R 3, InsP3R3, Type 3 inositol 1, 4, 5-trisphosphate receptor, Type 3 InsP3 receptor, ITPR3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ITPR3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITPR3 (HGNC:6182) |
|---|---|
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q63269}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q8WN95}; Multi-pass membrane protein. Note=Also localizes at mitochondria-associated membranes (MAMs). {ECO:0000250|UniProtKB:P70227} |
| Tissue Location | Expressed in intestinal crypt and villus epithelial cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
No cross-reactivity expected with other types of ITPR
References
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Futatsugi A, Nakamura T, Yamada MK, Ebisui E, Nakamura K, Uchida K, Kitaguchi T, Takahashi-Iwanaga H, Noda T, Aruga J, Mikoshiba K. Science. 2005 Sep 30;309(5744):2232-4. PMID: 16195467
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