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EVC2 / Limbin Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q86UK5 |
| Other Accession | NP_667338.3, NP_001159608.1, 132884 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 147948 Da |
| Gene ID | 132884 |
|---|---|
| Other Names | Limbin, Ellis-van Creveld syndrome protein 2, EVC2, EVC2, LBN |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EVC2 / Limbin Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EVC2 |
|---|---|
| Synonyms | LBN |
| Function | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8K1G2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8K1G2} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8K1G2}. Nucleus {ECO:0000250|UniProtKB:Q8K1G2} Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner {ECO:0000250|UniProtKB:Q8K1G2} |
| Tissue Location | Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise isoform 1 (NP_667338.3) and isoform 2 (NP_001159608.1).
References
Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism. Takeda H, Takami M, Oguni T, Tsuji T, Yoneda K, Sato H, Ihara N, Itoh T, Kata SR, Mishina Y, Womack JE, Moritomo Y, Sugimoto Y, Kunieda T. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10549-54. PMID: 12136126
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