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RNF35 / TRIM40 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6P9F5 |
| Other Accession | NP_619645.1, 135644 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 29336 Da |
| Gene ID | 135644 |
|---|---|
| Other Names | Tripartite motif-containing protein 40, Probable E3 NEDD8-protein ligase, RING finger protein 35, TRIM40, RNF35 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNF35 / TRIM40 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM40 |
|---|---|
| Synonyms | RNF35 |
| Function | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). |
| Tissue Location | Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
The RING finger. A novel protein sequence motif related to the zinc finger. Freemont PS. Ann N Y Acad Sci. 1993 Jun 11;684:174-92. Review. No abstract available. PMID: 8317827
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