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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Tensin 1 / TNS1 Antibody (C-Term)
Tensin 1 / TNS1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9HBL0 |
| Other Accession | NP_072174.3, 7145, 21961 (mouse), 301509 (rat) |
| Predicted | Human, Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 197023 Da |
| Gene ID | 7145 |
|---|---|
| Other Names | Tensin-1, TNS1, TNS |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Tensin 1 / TNS1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNS1 |
|---|---|
| Synonyms | TNS |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). |
| Cellular Location | Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localizes to both focal adhesions and fibrillar adhesions (PubMed:20069572). Localized at the cell periphery preferentially to fibrillar adhesions rather than to focal adhesions. Translocates from the cell edge to the cell center in an ITGB1BP1-dependent manner (PubMed:21768292) |
| Tissue Location | In the lung, detected in the alveolar septa (at protein level) (PubMed:28005397). Ubiquitous (PubMed:11023826) |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Molecular characterization of human tensin. Chen H, Ishii A, Wong WK, Chen LB, Lo SH. Biochem J. 2000 Oct 15;351 Pt 2:403-11. PMID: 11023826
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$ 423.00
Cat# AF2243a
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