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Goat Anti-TRPM7 / LTRPC7 Antibody

Peptide-affinity purified goat antibody

     
  • IHC - Goat Anti-TRPM7 / LTRPC7 Antibody AF2117a
    AF2117a (4 µg/ml) staining of paraffin embedded Mouse Hippocampus. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Similar results were obtained after antigen retrieval at pH9.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q96QT4
Other Accession NP_060142, 54822
Reactivity Mouse, Rat, Fish
Predicted Human, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 212697 Da
Additional Information
Gene ID 54822
Other Names Transient receptor potential cation channel subfamily M member 7, 2.7.11.1, Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTrpC7, TRPM7, CHAK1, LTRPC7
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TRPM7 / LTRPC7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM7
Synonyms CHAK1, LTRPC7 {ECO:0000303|PubMed:113855
Function Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644).
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q923J1}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q923J1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q923J1}. Note=Localized largely in intracellular Zn(2+)-storage vesicles. {ECO:0000250|UniProtKB:Q923J1}
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.

References

TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Du J, et al. Circ Res, 2010 Mar 19. PMID 20075334. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. Su LT, et al. J Mol Biol, 2010 Mar 5. PMID 20070945. Identification of TRPM7 channels in human intestinal interstitial cells of Cajal. Kim BJ, et al. World J Gastroenterol, 2009 Dec 14. PMID 19998500. Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. Romero JR, et al. Stroke, 2009 Sep. PMID 19644062. Evidence that TRPM7 is required for breast cancer cell proliferation. Guilbert A, et al. Am J Physiol Cell Physiol, 2009 Sep. PMID 19515901.

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$ 341.00
Cat# AF2117a
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