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Goat Anti-Triosephosphate isomerase Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, Pep-ELISA |
|---|---|
| Primary Accession | P60174 |
| Other Accession | NP_001152759, 7167 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5mg/ml |
| Isotype | IgG |
| Calculated MW | 26669 Da |
| Gene ID | 7167 |
|---|---|
| Other Names | Triosephosphate isomerase, TIM, 5.3.1.1, Triose-phosphate isomerase, TPI1, TPI |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Triosephosphate isomerase Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPI1 |
|---|---|
| Synonyms | TPI |
| Function | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. |
| Cellular Location | Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
References
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030. Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene. Fermo E, et al. Eur J Haematol, 2010 Aug. PMID 20374271. [Identification and expression of two new secretory proteins associated with prostate cancer] Qian XL, et al. Yi Chuan, 2010 Mar. PMID 20233700. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. Martins-de-Souza D, et al. BMC Psychiatry, 2009 Apr 30. PMID 19405953. Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples. Manco L, et al. Am J Hum Biol, 2009 Jan-Feb. PMID 18792062.
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