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Goat Anti-STMN2 / SCG10 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-STMN2 / SCG10 Antibody AF2044a
    AF2044a staining (1 µg/ml) of Human Brain lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q93045
Other Accession NP_008960, 11075, 20257 (mouse)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 20828 Da
Additional Information
Gene ID 11075
Other Names Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SCG10, SCGN10
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-STMN2 / SCG10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STMN2
Synonyms SCG10, SCGN10
Function Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane- bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.
Tissue Location Neuron specific.
Research Areas
Citations (0)
citation

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Background

Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).

References

Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Mead S, et al. Lancet Neurol, 2009 Jan. PMID 19081515.
Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. Li YH, et al. J Biol Chem, 2009 Jan 2. PMID 18996843.
Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. Chiellini C, et al. Biochem Biophys Res Commun, 2008 Sep 12. PMID 18611392.
The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Mahapatra NR, et al. Biochemistry, 2008 Jul 8. PMID 18549247.
BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. Gong Y, et al. BMB Rep, 2008 Apr 30. PMID 18452648.

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$ 341.00
Cat# AF2044a
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