Goat Anti-SEL1L Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9UBV2 |
Other Accession | NP_005056, 6400, 20338 (mouse), 314352 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 88755 Da |
Gene ID | 6400 |
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Other Names | Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L, SEL1L, TSA305 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-SEL1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SEL1L |
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Synonyms | TSA305 |
Function | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
References
Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Ban HJ, et al. BMC Genet, 2010 Apr 23. PMID 20416077.
A luminal flavoprotein in endoplasmic reticulum-associated degradation. Riemer J, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706418.
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Cormier JH, et al. Mol Cell, 2009 Jun 12. PMID 19524542.
Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate. Cattaneo M, et al. J Biol Chem, 2009 Apr 24. PMID 19204006.
Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Oresic K, et al. Biosci Rep, 2009 Jun. PMID 18811591.
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