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Goat Anti-RBP4 (Internal) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P02753 |
| Other Accession | NP_006735, 5950, 19662 (mouse), 25703 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 23010 Da |
| Gene ID | 5950 |
|---|---|
| Other Names | Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-RBP4 (Internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBP4 |
|---|---|
| Function | Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma and in urine (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
References
[Expression and regulation of retinol binding protein 4 mRNA in human adipose tissue in obese and type 2 diabetics] Liu XH, et al. Zhonghua Yi Xue Za Zhi, 2010 May 11. PMID 20646597.
Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. Nair AK, et al. PLoS One, 2010 Jul 6. PMID 20625434.
Decreased retinol binding protein 4 concentrations are associated with cholesterol gallstone disease. Wang SN, et al. J Formos Med Assoc, 2010 Jun. PMID 20610143.
Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance. Yeste D, et al. Horm Res Paediatr, 2010. PMID 20389103.
Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients. Shim CY, et al. Yonsei Med J, 2010 May. PMID 20376890.
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