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Goat Anti-PAX8 (internal) Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-PAX8 (internal) Antibody AF1794a
    HEK293 overexpressing PAX8A (RC200651) and probed with AF1794a (mock transfection in first lane), tested by Origene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q06710
Other Accession NP_054698, 7849
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 48218 Da
Additional Information
Gene ID 7849
Other Names Paired box protein Pax-8, PAX8
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PAX8 (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX8
Function Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Cellular Location Nucleus.
Tissue Location Expressed in the excretory system, thyroid gland and Wilms tumors
Research Areas
Citations (0)
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Background

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.

References

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor Pax-8. Scaloni A, et al. Methods Enzymol, 2010. PMID 20513481.
Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. Nitsch R, et al. BMC Genomics, 2010 May 14. PMID 20470391.
PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. Albadine R, et al. Am J Surg Pathol, 2010 Jul. PMID 20463571.
PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Long KB, et al. Am J Surg Pathol, 2010 May. PMID 20414099.

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$ 341.00
Cat# AF1794a
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