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Goat Anti-OIP106 / TRAK1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPV9 |
| Other Accession | NP_001036111, 22906 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 106040 Da |
| Gene ID | 22906 |
|---|---|
| Other Names | Trafficking kinesin-binding protein 1, 106 kDa O-GlcNAc transferase-interacting protein, TRAK1, KIAA1042, OIP106 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-OIP106 / TRAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRAK1 |
|---|---|
| Synonyms | KIAA1042, OIP106 |
| Function | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Mitochondrion membrane. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6PD31}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298). |
| Tissue Location | High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined Expressed in all cell lines examined. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker. Zhang F, et al. Cancer Lett, 2009 Feb 18. PMID 18986759.
Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. Webber E, et al. J Mol Biol, 2008 Oct 10. PMID 18675823.
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Fransson S, et al. Biochem Biophys Res Commun, 2006 Jun 2. PMID 16630562.
The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
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