Goat Anti-KLF8 / BKLF3 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O95600 |
Other Accession | NP_001152768, 11279 |
Reactivity | Human |
Predicted | Pig |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 39314 Da |
Gene ID | 11279 |
---|---|
Other Names | Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741, KLF8, BKLF3, ZNF741 |
Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-KLF8 / BKLF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLF8 |
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Synonyms | BKLF3, ZNF741 |
Function | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
References
Small interference RNA targeting Kr脤ppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. Fu WJ, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20182889.
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang X, et al. J Biol Chem, 2008 May 16. PMID 18353772.
Kr脤ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang X, et al. Cancer Res, 2007 Aug 1. PMID 17671186.
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. Hu JH, et al. J Mol Biol, 2007 Mar 2. PMID 17224162.
KLF8 transcription factor participates in oncogenic transformation. Wang X, et al. Oncogene, 2007 Jan 18. PMID 16832343.
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