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Goat Anti-Kinesin 1 / UKHC Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, Pep-ELISA |
|---|---|
| Primary Accession | P33176 |
| Other Accession | NP_004512, 3799 |
| Reactivity | Human, Dog |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 109685 Da |
| Gene ID | 3799 |
|---|---|
| Other Names | Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Kinesin 1 / UKHC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIF5B (HGNC:6324) |
|---|---|
| Synonyms | KNS, KNS1 |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. Seeger MA, et al. J Biol Chem, 2010 Mar 12. PMID 20071331.
Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane. Morton AM, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19913510.
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. Trejo HE, et al. FASEB J, 2010 Feb. PMID 19773350.
Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. Zadeh AD, et al. J Physiol, 2009 Oct 1. PMID 19675065.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
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