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Goat Anti-HIP-55 / SH3P7 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-HIP-55 / SH3P7 Antibody AF1528a
    AF1528a staining (1 µg/ml) of Jurkat lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UJU6
Other Accession NP_001116428, 28988, 13169 (mouse), 83527 (rat)
Reactivity Human, Mouse
Predicted Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 48207 Da
Additional Information
Gene ID 28988
Other Names Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55 kDa, HIP-55, SH3 domain-containing protein 7, DBNL, CMAP, SH3P7
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-HIP-55 / SH3P7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DBNL
Synonyms CMAP, SH3P7
Function Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q62418}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHL4}. Synapse {ECO:0000250|UniProtKB:Q62418} Perikaryon {ECO:0000250|UniProtKB:Q62418}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62418}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHL4}. Postsynaptic density {ECO:0000250|UniProtKB:Q9JHL4}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250|UniProtKB:Q62418, ECO:0000250|UniProtKB:Q9JHL4}
Research Areas
Citations (0)
citation

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References

An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.
The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation. Haeckel A, et al. J Neurosci, 2008 Oct 1. PMID 18829961.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55. Le Bras S, et al. FEBS Lett, 2007 Mar 6. PMID 17306257.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.

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$ 341.00
Cat# AF1528a
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