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Goat Anti-Gelsolin / GSN Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P06396 |
| Other Accession | NP_937895, 2934, 227753 (mouse), 296654 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 85698 Da |
| Gene ID | 2934 |
|---|---|
| Other Names | Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Gelsolin / GSN Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSN |
|---|---|
| Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). |
| Cellular Location | [Isoform 2]: Cytoplasm, cytoskeleton. |
| Tissue Location | Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene binds to the plus ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
The potential role of plasma gelsolin in dialysis-related protein-energy wasting. Lee PS, et al. Blood Purif, 2010. PMID 20093811.
Gelsolin in human colon adenocarcinoma cells with different metastatic potential. Litwin M, et al. Acta Biochim Pol, 2009. PMID 19956804.
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Solomon JP, et al. Biochemistry, 2009 Dec 8. PMID 19904968.
Proteomics of tumor-specific proteins in cerebrospinal fluid of patients with astrocytoma: usefulness of gelsolin protein. Ohnishi M, et al. Pathol Int, 2009 Nov. PMID 19883430.
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