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Goat Anti-EBF1 / COE1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP, E |
|---|---|
| Primary Accession | Q9UH73 |
| Other Accession | NP_076870, 1879, 13591 (mouse), 116543 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 64464 Da |
| Gene ID | 1879 |
|---|---|
| Other Names | Transcription factor COE1, O/E-1, OE-1, Early B-cell factor, EBF1, COE1, EBF |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-EBF1 / COE1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EBF1 |
|---|---|
| Synonyms | COE1, EBF |
| Function | Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B- cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Okamoto R, et al. Haematologica, 2010 Sep. PMID 20435627.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. Sombekke MH, et al. Mult Scler, 2010 Jun. PMID 20378664.
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Roessler S, et al. Mol Cell Biol, 2007 Jan. PMID 17101802.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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