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Goat Anti-CD20 / MS4A1 (C Terminus) Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-CD20 / MS4A1 (C Terminus) Antibody AF1214a
    AF1214a (0.05 µg/ml) staining of Human Lymph Node lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P11836
Other Accession NP_690605, 931
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 33077 Da
Additional Information
Gene ID 931
Other Names B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-CD20 / MS4A1 (C Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MS4A1
Synonyms CD20
Function B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Tissue Location Expressed on B-cells.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

References

Double-Hit mature B-cell lymphomas show a common immunophenotype by flow cytometry that includes decreased CD20 expression. Wu D, et al. Am J Clin Pathol, 2010 Aug. PMID 20660329.
In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling. de Haij S, et al. Cancer Res, 2010 Apr 15. PMID 20354182.
CD20 as a target for therapeutic type I and II monoclonal antibodies. Beers SA, et al. Semin Hematol, 2010 Apr. PMID 20350657.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
CD20 deficiency in humans results in impaired T cell-independent antibody responses. Kuijpers TW, et al. J Clin Invest, 2010 Jan 4. PMID 20038800.

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$ 341.00
Cat# AF1214a
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Availability: 7-10 days
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