Phospho-Her3 (ErbB3)-Y1328 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, IF |
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Primary Accession | P21860 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Concentration | 1mg/ml |
Isotype | Rabbit IgG |
Calculated MW | 148098 Da |
Gene ID | 2065 |
---|---|
Other Names | Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3 |
Target/Specificity | The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site. |
Dilution | WB~~1:500~1:1000 IHC~~1:50~1:100 IF~~1:100~200 |
Format | affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Phospho-Her3 (ErbB3)-Y1328 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ERBB3 |
---|---|
Synonyms | HER3 |
Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Epithelial tissues and brain. |

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