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Functional IL-1R2 (mouse) Antibody, mAb (recombinant)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, E |
|---|---|
| Primary Accession | P27931 |
| Reactivity | Mouse |
| Host | Purified From HEK 293 Cell culture Supernatant. |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2bλ |
| Gene Source | Mouse |
| Endotoxin | <0.01EU/ µg purified protein (LAL-test; Lonza). |
| Application Note | ,E,Detection,FC(1:100), |
| Clone Names | Praxy-1-1 |
| Calculated MW | 45645 Da |
| Description | IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the mouse IgG2b Fc domain. |
| Gene ID | 16178 |
|---|---|
| Other Names | CD121 Antigen-like Family Member B; IL-1 Type II Receptor; Interleukin-1 Receptor β Interleukin-1 Receptor Type II; CD121b |
| Target/Specificity | Recognizes mouse IL-1R2. |
| Format | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional IL-1R2 (mouse) Antibody, mAb (recombinant) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Il1r2 |
|---|---|
| Synonyms | Il-1r2, Il1rb |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane. Secreted |
| Tissue Location | Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The inflammatory actions of IL-1α and -β- depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
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