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Functional LAG-3 Antibody, mAb (blocking)

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E, IP
Primary Accession P18627
Reactivity Human, Monkey
Host Purified From Concentrated Hybridoma Tissue Culture Supernatant.
Clonality Monoclonal
Isotype Mouse IgG1
Gene Source Human
Endotoxin <0.001EU/ µg purified protein or <1EU/mg purified protein (LAL test; Lonza).
Application Note E,Functional Application,Inhibition,ICC,IHC,IP(10 µg/ml),WB(5 µg/ml)
Clone Names 11E3
Calculated MW 57449 Da
Additional Information
Gene ID 3902
Other Names Lymphocyte Activation Gene-3; FDC Protein; CD223
Target/Specificity Recognizes human and monkey LAG-3.
Format Liquid. In PBS containing 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional LAG-3 Antibody, mAb (blocking) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAG3 (HGNC:6476)
Synonyms FDC
Function Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).
Cellular Location [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein
Tissue Location Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
Research Areas
Citations (0)
citation

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Background

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

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$ 360.00
Cat# ADP0015
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