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Functional TRAIL-R1 (human) Antibody, mAb(preservative free)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, ICC, IP |
|---|---|
| Primary Accession | O00220 |
| Reactivity | Human |
| Host | Purified From Concentrated Hybridoma Tissue Culture Supernatant. |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Gene Source | Human |
| Application Note | FC,Functional Application, Inhibition (blocks TRAIL-R1 mediated killing if applied in solution),ICC,IP, |
| Clone Names | HS101 |
| Calculated MW | 50089 Da |
| Gene ID | 8797 |
|---|---|
| Other Names | TRAIL Receptor 1; DR4; APO2; TNFRSF10A; CD261 |
| Target/Specificity | Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4. |
| Format | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Reconstitution & Storage | Stable for at least 1 year after receipt when stored at -20°C. |
| Precautions | Functional TRAIL-R1 (human) Antibody, mAb(preservative free) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF10A |
|---|---|
| Synonyms | APO2, DR4, TRAILR1 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft. Cytoplasm, cytosol. Note=Palmitoylation is required for association with membranes. |
| Tissue Location | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K- 562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa.
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