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GS
Mouse Monoclonal antibody(Mab)
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P15104 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 648K5B2 |
| Calculated MW | 42064 Da |
| Gene ID | 2752 |
|---|---|
| Gene Name | GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341} |
| Other Names | Glutamine synthetase, GS, 6.3.1.2, Glutamate--ammonia ligase, Palmitoyltransferase GLUL, 2.3.1.225, GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341} |
| Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
| Storage | This product is stored at 2-8 ℃, please use it within the expiration date. |
| Precautions | Glutamine Synthetase Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341} |
|---|---|
| Function | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). |
| Cellular Location | Cytoplasm, cytosol. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane; Lipid-anchor. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane |
| Tissue Location | Expressed in endothelial cells. |
Research Areas
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Application Protocols
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Cat# AD80411-010
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