ERCC1
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P07992 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Clone Names | 856B4C4 |
Calculated MW | 32562 Da |
Gene ID | 2067 |
---|---|
Gene Name | ERCC1 |
Other Names | DNA excision repair protein ERCC-1, ERCC1 |
Dilution | IHC-P~~Ready-to-use |
Storage | This product is stored at 2-8 ℃, please use it within the expiration date. |
Precautions | ERCC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ERCC1 |
---|---|
Function | Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. |
Cellular Location | Isoform 1: Nucleus. Isoform 3: Nucleus. |
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