MBP
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P02686 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Clone Names | 564B1D5 |
Calculated MW | 33117 Da |
Gene ID | 4155 |
---|---|
Gene Name | MBP |
Other Names | Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP |
Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
Storage | This product is stored at 2-8 ℃, please use it within the expiration date. |
Precautions | Myelin Basic Protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MBP |
---|---|
Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
Cellular Location | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin |
Tissue Location | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system |
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