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CD45
Rabbit Monoclonal antibody(Mab)
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Application 
| IHC-P |
|---|---|
| Primary Accession | P08575 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | 154B1H9 |
| Calculated MW | 147486 Da |
| Gene ID | 5788 |
|---|---|
| Gene Name | PTPRC (HGNC:9666) |
| Other Names | Receptor-type tyrosine-protein phosphatase C, 3.1.3.48, Leukocyte common antigen, L-CA, T200, CD45, PTPRC (HGNC:9666), CD45 |
| Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | CD45 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPRC (HGNC:9666) |
|---|---|
| Synonyms | CD45 |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft Note=Colocalized with DPP4 in membrane rafts |
| Tissue Location | Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AD80064-010
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