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CD3
Rabbit Monoclonal antibody(Mab)
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- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P04234 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | 230B2F6 |
| Calculated MW | 18930 Da |
| Gene ID | 915 |
|---|---|
| Gene Name | CD3D |
| Other Names | T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, CD3d, CD3D, T3D |
| Dilution | IHC-P~~Ready-to-use IHC~~Ready-to-use |
| Storage | This product is stored at 2-8 ℃, please use it within the expiration date. |
| Precautions | CD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD3D |
|---|---|
| Synonyms | T3D |
| Function | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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If you have any additional inquiries please email technical services at tech@abcepta.com.
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Cat# AD80004-010
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