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Anti-Pyruvate Dehydrogenase E2 Antibody (4A4-B6-C10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP |
|---|---|
| Primary Accession | P10515 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 4A4-B6-C10 |
| Calculated MW | 68997 Da |
| Gene ID | 1737 |
|---|---|
| Application & Usage | WB: Jurkat, A549, U251, F9, Lncap and Hela cell lysates, |
| Other Names | 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, PBC, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex component E2 |
| Target/Specificity | Pyruvate Dehydrogenase E2 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-Pyruvate Dehydrogenase E2 Antibody (4A4-B6-C10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DLAT (HGNC:2896) |
|---|---|
| Synonyms | DLTA |
| Function | As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). |
| Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P08461} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle
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