BNP Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | P16860 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 14726 Da |
Gene ID | 4879 |
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Positive Control | Western Blot: human BNP |
Application & Usage | Western blot: 1-4 µg |
Other Names | NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide |
Target/Specificity | BNP |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | BNP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NPPB |
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Function | [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:1672777, PubMed:17372040, PubMed:1914098, PubMed:9458824). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed:21098034, PubMed:25339504, PubMed:9458824). Involved in regulating the extracellular fluid volume and maintaining the fluid- electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:1914098, PubMed:9458824). Binds the clearance receptor NPR3 (PubMed:16870210). |
Cellular Location | [NT-proBNP]: Secreted Note=Detected in blood. [Brain natriuretic peptide 32]: Secreted. Note=Detected in blood. |
Tissue Location | [Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2136732, PubMed:2138890) Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. It helps to restore the body's salt and H₂O balance and improves heart function
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