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Caper Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q14498 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59380 Da |
| Gene ID | 9584 |
|---|---|
| Application & Usage | Western blotting (1:500 – 1:2500) and Immunoprecipitation. HeLa cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the Caper of human and mouse origins. Reactivity to other species has not been tested. |
| Other Names | RNPC2, RNA-binding region containing protein 2, Caper, Coactivator of activating protein-1 and estrogen receptors, HCC1, Hepatocellular carcinoma protein 1, Splicing factor CC1.3, Splicing factor CC1.4 |
| Target/Specificity | Caper |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Caper Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBM39 {ECO:0000303|PubMed:28302793, ECO:0000312|HGNC:HGNC:15923} |
|---|---|
| Function | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). |
| Cellular Location | Nucleus speckle. Note=Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358) |
| Tissue Location | Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Caper, also known as splicing factor HCC1 or hepatocellular carcinoma protein 1 and RNA binding region containing protein 2 (RNPC2), acts as a transcriptional coactivator for steroid nuclear receptors c-Jun, ERalpha and ER-beta. Caper, a nuclear protein with highest concentrations in nuclear speckles, plays a role in the pre-mRNA splicing process. Two isoforms of Caper, HCC1.3 and HCC1.4, co-localize with pre-mRNA splicing factor SC35 and uridine-rich small nuclear RNAs. Caper is a widely expressed protein with highest levels detected in skeletal muscle, lung, brain and pancreas.
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