Anti-Phospho-ErbB 3 (Y1289) Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | P21860 |
Host | Rabbit |
Isotype | Rabbit IgG |
Reactivity | Human |
Clonality | Monoclonal |
Format | Liquid |
Description | Anti-Phospho-ErbB 3 (Y1289) Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human. |
Gene ID | 2065 |
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Other Names | Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3 |
Calculated MW | 148098 Da |
Application Details | WB 1:500-1:2000 |
Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Clone Names | Clone: 32E64 |
Immunogen | A synthesized peptide derived from human Phospho-ErbB 3 (Y1289) |
Purification | Affinity-chromatography |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | ERBB3 |
---|---|
Synonyms | HER3 |
Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Epithelial tissues and brain. |
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