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> home > Products > Primary Antibodies > Signal Transduction > Anti-Phospho-PLCB3 (S537) Rabbit Monoclonal Antibody
Anti-Phospho-PLCB3 (S537) Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q01970 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Phospho-PLCB3 (S537) Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human. |
| Gene ID | 5331 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, 3.1.4.11, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3 {ECO:0000312|EMBL:AAA77683.1} |
| Calculated MW | 138799 Da |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 32P57 |
| Immunogen | A synthesized peptide derived from human Phospho-PLCB3 (S537) |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PLCB3 {ECO:0000303|PubMed:20966218, ECO:0000312|EMBL:AAA77683.1} |
|---|---|
| Function | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). |
| Cellular Location | Cytoplasm. Membrane {ECO:0000250|UniProtKB:Q99JE6}. Nucleus {ECO:0000250|UniProtKB:P51432} Note=And particulate fractions. {ECO:0000250|UniProtKB:Q99JE6} |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16786
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