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Anti-Phospho-Phospholamban (S16) Rabbit Monoclonal Antibody

     
  •  - Anti-Phospho-Phospholamban (S16) Rabbit Monoclonal Antibody ABO16784
    All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature.
    detail
  •  - Anti-Phospho-Phospholamban (S16) Rabbit Monoclonal Antibody ABO16784
    All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P26678
Host Rabbit
Isotype Rabbit IgG
Reactivity Human, Mouse
Clonality Monoclonal
Format Liquid
Description Anti-Phospho-Phospholamban (S16) Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human, Mouse.
Additional Information
Gene ID 5350
Other Names Cardiac phospholamban, PLB, PLN (HGNC:9080), PLB
Calculated MW 6109 Da
Application Details WB 1:500-1:2000
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: 32P55
Immunogen A synthesized peptide derived from human Phospho-Phospholamban (S16)
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name PLN (HGNC:9080)
Synonyms PLB
Function Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein. Note=Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
Tissue Location Heart muscle (at protein level).
Research Areas
Citations (0)
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$ 370.00
Cat# ABO16784
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