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> home > Products > Primary Antibodies > Signal Transduction > Anti-phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) Rabbit Monoclonal Antibody
Anti-phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P19174 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human. |
| Gene ID | 5335 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1, 3.1.4.11, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1 (HGNC:9065), PLC1 |
| Calculated MW | 148532 Da |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 32P05 |
| Immunogen | A synthesized peptide derived from human phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PLCG1 (HGNC:9065) |
|---|---|
| Synonyms | PLC1 |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). |
| Cellular Location | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16734
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