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> home > Products > Primary Antibodies > Signal Transduction > Anti-Ceruloplasmin Rabbit Monoclonal Antibody
Anti-Ceruloplasmin Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P00450 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Ceruloplasmin Rabbit Monoclonal Antibody . Tested in WB applications. This antibody reacts with Human, Rat. |
| Gene ID | 1356 |
|---|---|
| Other Names | Ceruloplasmin, Cuproxidase ceruloplasmin, 1.16.3.4, Ferroxidase ceruloplasmin, 1.16.3.1, Glutathione peroxidase ceruloplasmin, 1.11.1.9, Glutathione-dependent peroxiredoxin ceruloplasmin, 1.11.1.27, CP (HGNC:2295) |
| Calculated MW | 122219 Da |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 31C62 |
| Immunogen | A synthesized peptide derived from human Ceruloplasmin |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CP (HGNC:2295) |
|---|---|
| Function | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo- transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). |
| Cellular Location | Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments {ECO:0000250|UniProtKB:P13635} |
| Tissue Location | Expressed by the liver and secreted in plasma. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16691
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